Tyrosine-protein kinase receptor UFO (AXL). Receptor
tyrosine kinase that transduces signals from the extracellular matrix
into the cytoplasm by binding growth factor GAS6 and which is thus
regulating many physiological processes including cell survival, cell
proliferation, migration and differentiation.
NCT03393936 - Renal Cancer
The following plot describes the target topology, highlighting the
position of the endo-, ecto- and transmembrane domains, as well as the
position of a signal peptide, when present. The last three rows describe
the position of potential epitopes, as well as phosphorylation and
glycosylation sites.